Euro
USD
British Pound
NULL
![CD80 Antibody [1G10] (Biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576584/814446/porsci_lo__79508.1648973713__56891.1649092227.png?c=2 "CD80 Antibody [1G10] (Biotin)")
![CD80 Antibody [1G10] (Biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/576584/814446/porsci_lo__79508.1648973713__56891.1649092227.png?c=2 "CD80 Antibody [1G10] (Biotin)")
Product Description
CD80 Antibody [1G10] (Biotin) | 98-847 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: Activated 5C2 cells
Research Area: Immunology, Signal Transduction
Tested Application: Flow
Application: CD80 Antibody [1G10] for use in flow cytometry and immunoprecipitation assays.
Specificiy: CD80
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [1G10]
Isotype: IgG2a
Conjugate: Biotin
Physical State: Liquid
Buffer: Supplied in PBS/NaN3
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: B7-1, Ly-53
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor crosslinking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80 with its ligands, CD28 and CD152 (CTLA-4) , provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80 but it does not block stimulation of T cells by natural antigen-presenting cells.
![CD80 Antibody [1G10] (Biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/576584/814446/porsci_lo__79508.1648973713__56891.1649092227.png?c=2 "CD80 Antibody [1G10] (Biotin)")
![CD80 Antibody [1G10]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/576582/814443/porsci_lo__79508.1648973713__75249.1649092227.png?c=2 "CD80 Antibody [1G10]")
![CD80 Antibody [1G10]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/576585/814448/porsci_lo__79508.1648973713__42886.1649092227.png?c=2 "CD80 Antibody [1G10]")
![CD80 Antibody [1G10] (FITC)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/576583/814444/porsci_lo__79508.1648973713__32154.1649092227.png?c=2 "CD80 Antibody [1G10] (FITC)")
![CD80 Antibody [1G10] (PE)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/576136/813746/porsci_lo__79508.1648973713__85549.1649092133.png?c=2 "CD80 Antibody [1G10] (PE)")
![CD80 Antibody [1G10] (APC)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/576137/813748/porsci_lo__79508.1648973713__66743.1649092134.png?c=2 "CD80 Antibody [1G10] (APC)")
![CD80 Antibody [1G10] (PE-Cy5)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/576138/813750/porsci_lo__79508.1648973713__81872.1649092134.png?c=2 "CD80 Antibody [1G10] (PE-Cy5)")
