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![CD8a Antibody [53-6.7] (FITC)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576464/814270/porsci_lo__79508.1648973713__46051.1649092204.png?c=2 "CD8a Antibody [53-6.7] (FITC)")
![CD8a Antibody [53-6.7] (FITC)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/576464/814270/porsci_lo__79508.1648973713__46051.1649092204.png?c=2 "CD8a Antibody [53-6.7] (FITC)")
Product Description
CD8a Antibody [53-6.7] (FITC) | 98-614 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: Spleen cells or thymocyte membranes
Research Area: Immunology
Tested Application: E, IHC-Fr, ICC
Application: CD8a Antibody [53-6.7] for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.
Specificiy: CD8alpha
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [53-6.7]
Isotype: IgG2a
Conjugate: FITC
Physical State: Liquid
Buffer: Supplied in PBS/NaN3
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Ly-2, Lyt-2, Ly-35, Ly-B, T8
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an alpha chain (CD8alpha) and a beta chain (CD8beta) ; and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8alpha without CD8beta. It has been suggested that CD8+beta- T cells mature extrathymically, while development of the CD8alpha+beta+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8alpha+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.
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