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![Ly-6A/E Antibody [D7] (APC)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576150/813775/porsci_lo__79508.1648973713__53581.1649092138.png?c=2 "Ly-6A/E Antibody [D7] (APC)")
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Product Description
Ly-6A/E Antibody [D7] (APC) | 98-878 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: IL-2 dependent mouse (C57BL/6) cytotoxic T cell line CTL-L
Research Area: Innate Immunity, Stem Cell
Tested Application: Flow
Application: Ly-6A/E Antibody [D7] for use in flow cytometry assays.
Specificiy: Ly-6A/E
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [D7]
Isotype: IgG2a
Conjugate: APC
Physical State: Liquid
Buffer: Supplied in PBS/NaN3 and a stabilizing agent
Concentration: 0.1 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Sca-1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.
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