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Product Description
VEZT Antibody | 7959 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: VEZT antibody was raised against a 17 amino acid peptide near the center of human VEZT.
The immunogen is located within amino acids 480 - 530 of VEZT.
Research Area: Stem Cell
Tested Application: E, WB, IHC-P, IF
Application: VEZT antibody can be used for detection of VEZT by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Specificiy: VEZT antibody is human, mouse and rat reactive. Multiple isoforms are known to exist.
Positive Control 1: Cat. No. 1210 - HEK293 Cell Lysate
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 63, 68, 78, 81, 83, 86 kDa
Observed: 60 kDa
Validation: N/A
Isoform: N/A
Purification: VEZT antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: VEZT antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: VEZT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: VEZT Antibody: VEZATIN, Vezatin
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Vezatin (VEZT) is a transmembrane protein which localizes to adherens junctions and binds to myosin VIIA and the cadherin-catenins complex (1) . Expression of this gene in gastric cancer tissues is decreased due to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts (2) . VEZT has also been shown to be required for morphogenesis of the preimplantation mouse embryo (3) .
