Euro
USD
British Pound
NULL
Product Description
2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.
2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism.
Biovision | B1048 | 2-Deoxy-D-Glucose DataSheet
Alternate Name/Synonyms: 2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 154-17-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₆H₁₂O₅
Molecular Weight: 164.16
Cell-Permeable?: Yes
Purity: ≥98% GC
Solubilities: H2O (>15 mg/ml) or DMSO (>15 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A competitive inhibitor of glucose metabolism.
MDL Number: MFCD00151328
PubChem CID: 439268
SMILES: C1C(C(C(OC1O)CO)O)O
InChi: InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1
InChi Key: PMMURAAUARKVCB-CERMHHMHSA-N
