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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • GSK-650394

    Biovision | GSK-650394 | B2093

    GSK-650394 is a potent inhibitor of serum- and glucocorticoid-regulated kinase (IC₅₀s = 62 and 103 nM for SGK1 and SGK2, respectively). It demonstrates greater than 30-fold selectivity for SGK1 over Akt and other related kinases. GSK-650394 can inhibit...

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  • GSK-583

    Biovision | GSK-583 | B1301

    GSK-583 is a highly potent and selective Inhibitor of RIP2 Kinase (IC₅₀ = 5 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2,...

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  • GSK-503

    Biovision | GSK-503 | 9538

    GSK-503 is a potent EZH2 inhibitor with potential anticancer activity. Increased activity of the epigenetic modifier EZH2 has been associated with different cancers. In a melanoma mouse model, conditional Ezh2 ablation as much as treatment with the...

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  • GSK-484 hydrochloride

    Biovision | GSK-484 hydrochloride | B1035

    GSK-484 is a potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK-484 blocks the citrullination of PAD4 target proteins in human...

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  • GSK-4112

    Biovision | GSK-4112 | 9663

    GSK-4112 is a selective agonist for REV-ERBα (EC₅₀ = 0.4 μM). At 10 μM, GSK-4112 can reset the circadian rhythm in a phasic manner by inhibiting expression of the circadian target gene bmal1 and reduce glucose output by 30% in mouse primary hepatocytes...

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  • GSK-3787

    Biovision | GSK-3787 | 2400

    GSK-3787 is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) (plC₅₀ = 6.6). It covalently binds to Cys 249 in the PPARδ binding site.GSK-3787 is a selective and irreversible antagonist of the...

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  • GSK-3117391

    Biovision | GSK-3117391 | B2375

    GSK-3117391 is a potent histone deacetylase (HDAC) inhibitorGSK-3117391 is a potent histone deacetylase (HDAC) inhibitorBiovision | B2375 | GSK-3117391 DataSheetAlternate Name/Synonyms:...

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  • GSK-3039294

    Biovision | GSK-3039294 | B2374

    GSK-3039294 is a potent small molecule inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils for the depletion of serum amyloid-P (SAP) component from the circulation.GSK-3039294 is a potent small molecule inhibitor of serum amyloid P...

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  • GSK-3 Inhibitor, AR-A014418

    Biovision | GSK-3 Inhibitor, AR-A014418 | 1953

    Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases...

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  • GSK-2982772

    Biovision | GSK-2982772 | B2232

    GSK-2982772 is a potent and ATP-competitive receptor-interacting protein-1 (RIP1) kinase inhibitor (IC₅₀ = 1 nM).GSK-2982772 is a potent and ATP-competitive receptor-interacting protein-1 (RIP1) kinase inhibitor (IC₅₀ = 1 nM).Biovision | B2232 |...

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  • GSK-2879552

    Biovision | GSK-2879552 | B1044

    GSK-2879552 is a potent, selective, mechanism-based inactivator of Lysine Specific Demethylase 1 (LSD1)/ CoRepressor for Element-1-Silencing Transcription factor (CoREST) activity. GSK-2879552 binds to and inhibits LSD1, a demethylase that suppresses the...

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  • GSK2830371

    Biovision | GSK2830371 | 2578

    GSK2830371 is an allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor (IC₅₀ of 6 nM). It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition. Due to lack of this domain in other phosphatases, its binding...

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  • GSK-2801

    Biovision | GSK-2801 | 9553

    GSK-2801 is a potent, selective and cell-permeable inhibitor of the BAZ2 family of bromodomain containing proteins. GSK-2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B and BAZ2A, respectively.GSK-2801 is a...

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  • GSK-269962

    Biovision | GSK-269962 | 9654

    GSK-269962 is a potent Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.GSK-269962 is a potent...

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  • GSK-2656157

    Biovision | GSK-2656157 | 9466

    GSK-2656157 is a potent, selective and ATP-competitive inhibitor of PERK (protein kinase R-like ER kinase) enzyme activity with an IC₅₀ of 0.9 nM; displays high selectivity for PERK against a panel of 300 kinases (IC₅₀>100 nM).GSK-2656157 is a potent,...

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  • GSK-2606414

    Biovision | GSK-2606414 | 9467

    GSK-2606414 is a potent and selective inhibitor of protein kinase R-like ER kinase (PERK) with IC₅₀ value of 0.4 nM. Displays >1000-fold selectivity for PERK over HR1 and PKR. GSK-2606414 inhibits PERK activation in cells and inhibits the growth of a...

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  • GSK-2334470

    Biovision | GSK-2334470 | B1555

    GSK-2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) (IC₅₀ = 10 nM). It does not suppress activity on other 96 kinases, including Aurora, ROCK, p38 MAPK and PI3K.GSK-2334470 is a highly specific...

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  • GSK2330672

    Biovision | GSK2330672 | B1102

    GSK2330672 is a highly selective, potent, nonabsorbable ASBT(Apical Sodium dependent bile acid transporter) inhibitor (IC₅₀ = 42 nM). It lowers glucose in an animal model of type 2 diabetes.GSK2330672 is a highly selective, potent, nonabsorbable...

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  • GSK-2194069

    Biovision | GSK-2194069 | B1571

    GSK-2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS (human Fatty Acid Synthase).GSK-2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS (human Fatty Acid Synthase)...

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  • GSK2190915

    Biovision | GSK2190915 | B1891

    GSK2190915 (Fiboflapon) is a potent FLAP (5-lipoxygenase-activating protein) inhibitor (IC₅₀ = 2.9 nM).GSK2190915 (Fiboflapon) is a potent FLAP (5-lipoxygenase-activating protein) inhibitor (IC₅₀ = 2.9 nM).Biovision | B1891 | GSK2190915...

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  • GSK-2126458

    Biovision | GSK-2126458 | 1961

    Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ), 0.18 nM (mTORC1), and 0.3 nM (mTORC2). In vivo,...

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  • GSK-2118436 mesylate

    Biovision | GSK-2118436 mesylate | 2800

    GSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC₅₀ of 0.8 nM, compared to wild type B-Raf and c-Raf with IC₅₀s of 3.2 nM and 5.0 nM,...

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  • GSK-2110183

    Biovision | GSK-2110183 | B1089

    GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM for Akt1, Akt2, and Akt3 respectively.GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM...

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  • GSK-2018682

    Biovision | GSK-2018682 | B1967

    GSK-2018682 is a potent sphingosine -1 phosphate receptor (S1PR)-1 agonist; useful for the treatment of multiple sclerosis. GSK-2018682 induces acute, transient and non-symptomatic decreases in heart rate and blood pressure.GSK-2018682 is a potent...

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  • GSK-199 hydrochloride

    Biovision | GSK-199 hydrochloride | B1037

    GSK-199 is a potent, reversible inhibitor of PAD4 (IC₅₀ = 200 nM. It binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3. It is less potent than the related PAD4 inhibitor GSK484 (IC₅₀ = 50 nM). GSK-199 can inhibit the...

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  • GSK-1940029

    Biovision | GSK-1940029 | B2373

    GSK-1940029 is a potent stearoyl-coA desaturase (SCD) inhibitorGSK-1940029 is a potent stearoyl-coA desaturase (SCD) inhibitorBiovision | B2373 | GSK-1940029 DataSheetAlternate Name/Synonyms:...

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  • GSK1349572

    Biovision | GSK1349572 | 2288

    A potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.GSK1349572 is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.Biovision | 2288 |...

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  • GSK1325756

    Biovision | GSK1325756 | B1103

    GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12.5 nM. GSK1325756 displays anti-inflammatory effects in various preclinical and clinical models.GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12...

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  • GSK-1292263

    Biovision | GSK-1292263 | B1556

    GSK-1292263 is a novel GPR119 receptor agonist and is used for the treatment of type 2 diabetes. GSK1292263 improves glucose regulation in animal models of diabetes, but has no effect on plasma glucose in type 2 diabetics.GSK-1292263 is a novel GPR119...

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  • GSK1278863

    Biovision | GSK1278863 | B1107

    GSK-1278863 is a novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (HIF-PHI). Hypoxia-inducible factor−prolyl hydroxylase inhibitors stimulate endogenous EPO synthesis and induce effective erythropoiesis by non-EPO effects.GSK-1278863 is a...

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  • GSK-121 trifluoroacetate

    Biovision | GSK-121 trifluoroacetate | B1034

    GSK-121 is a novel protein arginine deiminase 4 (PAD4) inhibitor. GSK-121 was shown to inhibit the citrullination of PAD4 target proteins in a functional assay with an IC₅₀ value of 3.2 µM.GSK-121 is a novel protein arginine deiminase 4 (PAD4) inhibitor...

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  • GSK-1120212

    Biovision | GSK-1120212 | 1960

    A potent and selective allosteric inhibitor of the MEK1 (IC₅₀ = 0.7 nM) and MEK2 (IC₅₀ = 0.9 nM) enzymes with potential antineoplastic activity.GSK-1120212 is a potent and selective allosteric inhibitor of the MEK1 (IC₅₀ = 0.7 nM) and MEK2 (IC₅₀ = 0.9...

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  • GSK-106 hydrochloride

    Biovision | GSK-106 hydrochloride | B1036

    GSK-106 is a useful negative control for PAD4 inhibitors (GSK-121 and GSK-484). It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils...

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  • GSK-1059615

    Biovision | GSK-1059615 | 9450

    GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It...

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  • GSK-0660

    Biovision | GSK-0660 | 2897

    GSK-0660 is a selective PPARδ antagonist (IC₅₀ values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ, respectively).GSK-0660 is a selective PPARδ antagonist (IC₅₀ values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ, respectively)...

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  • GS-9973

    Biovision | GS-9973 | 2669

    GS-9973 is a potent and highly selective Syk (spleen tyrosine kinase) inhibitor (IC₅₀ = 7.7 nM).GS-9973 is a potent and highly selective Syk (spleen tyrosine kinase) inhibitor (IC₅₀ = 7.7 nM).Biovision | 2669 | GS-9973 DataSheetAlternate Name/Synonyms:...

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  • Grazoprevir (MK-5172)

    Biovision | Grazoprevir (MK-5172) | B2337

    Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). Grazoprevir is a second-generation hepatitis C virus...

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  • GPNA (monohydrate)

    Biovision | GPNA (monohydrate) | B2150

    GPNA is a substrate for γ-glutamyl transpeptidase. GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5). Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that...

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  • Gossypin

    Biovision | Gossypin | 2374

    A glucoside occurring in cotton and Hubiscus flowers that acts as a potent antimelanoma agent. Gossypin inhibits human melanoma cell proliferation, in vitro, in melanoma cell lines that harbors both BRAF-V600E kinase and CDK4 as well as in cells with...

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  • GNE 477

    Biovision | GNE 477 | B1657

    GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.Biovision | B1657 | GNE...

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  • GN25

    Biovision | GN25 | 9430

    GN25 blocks Snail binding to p53 and induces p53 expression in cancer cells in a KRas dependent manner. Oncogenic KRas has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. At 10 μM, GN25 significantly...

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  • GLYX13

    Biovision | GLYX13 | B2287

    GLYX-13 is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Displays nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo.GLYX-13 is an...

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  • GLX-351322

    Biovision | GLX-351322 | B2340

    GLX-351322 is a potent NADPH oxidase-4 (NOX-4) inhibitor. Displays selectivity for NOX-4 over NOX-2. GLX-351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells (IC₅₀ = 5 µM).GLX-351322 is a potent NADPH...

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  • Glutathione ethyl ester

    Biovision | Glutathione ethyl ester | B2307

    Glutathione (GSH) ethyl ester is a cell-permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH ethyl ester has been used to protect cells against damage from radiation, oxidants, and...

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  • Glutaminase C-IN-1 (968)

    Biovision | Glutaminase C-IN-1 (968) | B1198

    Glutaminase C-IN-1 (968) a cell-permeable, reversible inhibitor of a mitochrondrial glutaminase splice variant, glutaminase C (IC₅₀ = ~2.5 µM), which is commonly found in cancer cells. Glutaminase C-IN-1 (968) blocks transformation induced by Rho GTPases...

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  • GLPG-1690

    Biovision | GLPG-1690 | B1850

    GLPG-1690 is a selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).GLPG-1690 is a selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).Biovision | B1850 | GLPG-1690...

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  • Globosuxanthone A

    Biovision | Globosuxanthone A | B2130

    Globosuxanthone A is a dihydroxyxanthenone isolated from Chaetomium globosum. It displays activity against several solid tumor cell lines, NCI-H460, MCF-7, SF-268, PC-3, PC-3M, LNCaP, and DU-145.Globosuxanthone A is a dihydroxyxanthenone isolated from...

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  • GKT-137831

    Biovision | GKT-137831 | 9444

    GKT-137831 is a novel pyrazolopyridinedione derivative that acts as a Nox4 and Nox1 inhibitor ((Ki 100–150 nM). GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Also a potent inhibitor of fibrosis and hepatocyte apoptosis...

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  • GJ-103 Sodium salt

    Biovision | GJ-103 Sodium salt | B1842

    GJ103 sodium salt is an active, water-soluble analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. It...

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  • Givinostat hydrochloride

    Biovision | Givinostat hydrochloride | B2081

    Givinostat is a potent hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated...

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  • Ginkgolic acid C15:1

    Biovision | Ginkgolic acid C15:1 | 9523

    Ginkgolic acid is a naturally occurring compound. It inhibits protein SUMOylation both in vitro and in vivo without affecting in vivo ubiquitination. Binding assays with a fluorescently labeled probe shows that ginkgolic acid directly binds E1 and...

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