Product Description
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC₅₀ of 100 nM.
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC₅₀ of 100 nM.
Biovision | 2859 | A-366 DataSheet
Alternate Name/Synonyms: 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
Appearance: Off-white solid
Formulation: N/A
CAS Number: 1527503-11-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₇N₃O₂
Molecular Weight: 329.44
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective G9a/GLP histone lysine methyltransferase inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: NC(C12CCC1)=NC3=C2C=C(OC)C(OCCCN4CCCC4)=C3
InChi: InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChi Key: BKCDJTRMYWSXMC-UHFFFAOYSA-N