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Product Description
Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.
Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.
Biovision | B1905 | Aclacinomycin A hydrochloride DataSheet
Alternate Name/Synonyms: Aclarubicin hydrochloride
Appearance: Orange solid
Formulation: N/A
CAS Number: 75443-99-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₄₂H₅₃NO₁₅ • HCl
Molecular Weight: 848.3
Cell-Permeable?: Yes
Purity: ≥90% by HPLC
Solubilities: DMSO (~ 30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A specific inhibitor of the 20S proteasome chymotrypsin-like activity.
MDL Number: MFCD00133024
PubChem CID: 153751
SMILES: CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O.Cl
InChi: InChI=1S/C42H53NO15.ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29;/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3;1H/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+;/m0./s1
InChi Key: KUSMIBXCRZTVML-PCCPLWKKSA-N
