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Product Description
AG-014699 phosphate is a potent, cell-permeable inhibitor of PARP1 with Ki of 1.4 nM. It selectively binds to PARP 1 and inhibits the PARP1-mediated DNA repair, thus potentiating the genomic instability and apoptosis. Displays antineoplastic activity.
AG-014699 phosphate is a potent, cell-permeable inhibitor of PARP1 with Ki of 1.4 nM. It selectively binds to PARP 1 and inhibits the PARP1-mediated DNA repair, thus potentiating the genomic instability and apoptosis. Displays antineoplastic activity.
Biovision | 2890 | AG-014699 phosphate DataSheet
Alternate Name/Synonyms: 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate; Rucaparib; PF-01367338
Appearance: Light yellow to yellow solid
Formulation: N/A
CAS Number: 459868-92-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₁FN₃O₅P
Molecular Weight: 421.36
Cell-Permeable?: yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~20 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent PARP1 inhibitor
MDL Number: N/A
PubChem CID: 9931953
SMILES: CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O
InChi: InChI=1S/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4)
InChi Key: FCCGJTKEKXUBFZ-UHFFFAOYSA-N
