Product Description
A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.
AICAR is a cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis.
Biovision | 1687 | AICAR DataSheet
Alternate Name/Synonyms: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823
Appearance: Tan powder
Formulation: N/A
CAS Number: 2627-69-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₉H₁₄N₄O₅
Molecular Weight: 258.23
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: H₂O
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: An AMPK activator
MDL Number: MFCD00869751
PubChem CID: 17513
SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N
InChi: InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChi Key: RTRQQBHATOEIAF-UUOKFMHZSA-N