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Product Description
A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC₅₀ >30 µM). Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.
AKR1C3 inhibitor II is a highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM).
Biovision | 2404 | AKR1C3 Inhibitor II DataSheet
Alternate Name/Synonyms: 1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one
Appearance: White to off-white solid
Formulation: N/A
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₁₆H₂₂N₂O₃S
Molecular Weight: 322.42
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly potent and selective AKR1C3 inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C1N(C2=CC=C(S(=O)(N3C(C)CCCC3)=O)C=C2)CCC1
InChi: InChI=1S/C16H22N2O3S/c1-13-5-2-3-12-18(13)22(20,21)15-9-7-14(8-10-15)17-11-4-6-16(17)19/h7-10,13H,2-6,11-12H2,1H3
InChi Key: KCSTYGPHSVKBQP-UHFFFAOYSA-N
