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Product Description
AX-024 is a T cell receptor (TCR) inhibitor. An orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC₅₀ = 1 nM). By modulating TCR signaling, the inhibitor prevents the development of psoriasis and asthma. Additionally, it exerts a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis.
AX-024 is a T cell receptor (TCR) inhibitor. An orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC₅₀ = 1 nM). By modulating TCR signaling, the inhibitor prevents the development of psoriasis and asthma. Additionally, it exerts a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis.
Biovision | B2013 | AX-024 hydrochloride DataSheet
Alternate Name/Synonyms: 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride; AX024
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1704801-24-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₂₂FNO₂.HCl
Molecular Weight: 375.86
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A T cell receptor (TCR) inhibitor
MDL Number: N/A
PubChem CID: 129909862
SMILES: COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4.Cl
InChi: InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H
InChi Key: DGBCIMPGYRVTPD-UHFFFAOYSA-N
