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Product Description
This is a synthetic peptide that irreversibly inhibits caspase-2 and related caspase activity. It is a biotinylated derivative of the Caspase-2 inhibitor Z-VDVAD-FMK (Cat # 1142). This conjugation with biotin allows detection of activated caspases in conjunction with avidin-tags. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Biotin-VDVAD-FMK is a biotinylated derivative of the Caspase-2 inhibitor Z-VDVAD-FMK (Cat # 1142).
Biovision | 1032 | Biotin-VDVAD-FMK DataSheet
Alternate Name/Synonyms: Biotin-VDVAD-FMK, VDVAD-FMK, Biotin
Appearance: Liquid
Formulation: DMSO (10 mM)
CAS Number: N/A
Structure Available?: No
Peptide sequence: Biotin-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
Salt Form: No
Molecular Formula: C₄₀H₆₅FN₈O₁₂S
Molecular Weight: 901.05
Cell-Permeable?: Yes
Purity: Single spot by TLC
Solubilities: N/A
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A Caspase-2 inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(OC)C[C@H](NC([C@@H](NC(C(C(C)C)NC([C@@H](NC(C(C(C)C)NC(CCCCCNC(CCCC[C@H]1SC[C@](N2)([H])[C@@]1([H])NC2=O)=O)=O)=O)CC(OC)=O)=O)=O)C)=O)C(CF)=O
InChi: InChI=1S/C40H65FN8O12S/c1-21(2)33(47-30(52)15-9-8-12-16-42-29(51)14-11-10-13-28-35-26(20-62-28)46-40(59)49-35)39(58)45-25(18-32(54)61-7)37(56)48-34(22(3)4)38(57)43-23(5)36(55)44-24(27(50)19-41)17-31(53)60-6/h21-26,28,33-35H,8-20H2,1-7H3,(H,42,51)(H,43,57)(H,44,55)(H,45,58)(H,47,52)(H,48,56)(H2,46,49,59)/t23-,24-,25-,26+,28+,33?,34?,35+/m0/s1
InChi Key: HZMQEZLCGJXARR-LFJGSYRESA-N
