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Product Description
10-Deacetylbaccatin III is a precursor in the semisynthetic synthesis of paclitaxel; acts as an inhibitor of microtubule assembly (IC₅₀s = 23 and 0.9 µM for porcine brain and Physaram microtubules, respectively). 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.
10-Deacetylbaccatin III is a precursor in the semisynthetic synthesis of paclitaxel; acts as an inhibitor of microtubule assembly (IC₅₀s = 23 and 0.9 µM for porcine brain and Physaram microtubules, respectively). 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.
Biovision | B2659 | 10-Deacetylbaccatin III DataSheet
Alternate Name/Synonyms: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; NSC 251677; NSC-251677
Appearance: White solid
Formulation:
CAS Number: 32981-86-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₃₆O₁₀
Molecular Weight: 544.6
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~20 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A microtubule assembly inhibitor
MDL Number: MFCD00132913
PubChem CID: 154272
SMILES: O[C@H]1C[C@@]([H])(OC2)[C@@]2([C@@]([H])([C@H](OC(C3=CC=CC=C3)=O)[C@@](C[C@@H](C(C)=C4[C@H]5O)O)(O)C4(C)C)[C@]1(C)C5=O)OC(C)=O
InChi: InChI=1S/C29H36O10/c1-14-17(31)12-29(36)24(38-25(35)16-9-7-6-8-10-16)22-27(5,23(34)21(33)20(14)26(29,3)4)18(32)11-19-28(22,13-37-19)39-15(2)30/h6-10,17-19,21-22,24,31-33,36H,11-13H2,1-5H3/t17-,18-,19+,21+,22-,24-,27+,28-,29+/m0/s1
InChi Key: YWLXLRUDGLRYDR-ZHPRIASZSA-N
