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Product Description
2,4-Pyridinedicarboxylic Acid is an inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases. It structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus inhibiting a range of enzymes. As a 2-OG mimic it also inhibits prolyl, collagen and lysyl hydroxylases. It modulates hypoxia-inducible factor turnover, collagen synthesis and plant cell wall formation. It also inhibits zinc-dependent enzymes, like metallo-β-lactamase. It inhibits several Jumonji domain-containing lysine demethylases such as JMJD2A (KDM4A) and KDM4C. It reduced neointimal hyperplasia and inflammation in the carotid arteries of Diabetic Rats.
2,4-Pyridinedicarboxylic Acid is an inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases. It structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus inhibiting a range of enzymes. As a 2-OG mimic it also inhibits prolyl, collagen and lysyl hydroxylases. It modulates hypoxia-inducible factor turnover, collagen synthesis and plant cell wall formation. It also inhibits zinc-dependent enzymes, like metallo-β-lactamase. It inhibits several Jumonji domain-containing lysine demethylases such as JMJD2A (KDM4A) and KDM4C. It reduced neointimal hyperplasia and inflammation in the carotid arteries of Diabetic Rats.
Biovision | B2809 | 2,4-Pyridinedicarboxylic Acid DataSheet
Alternate Name/Synonyms: 2,4-Lutidinic acid, 2,4-Dicarboxypyridine, 4-carboxypicolinic acid, histone lysine demethylase inhibitor, Lutidinic acid
Appearance: Crystalline solid
Formulation:
CAS Number: 499-80-9
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₇H₅NO₄
Molecular Weight: 167.12
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~1.4 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases
MDL Number: MFCD00006296
PubChem CID: 10365
SMILES: C1=CN=C(C=C1C(=O)O)C(=O)O
InChi: InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChi Key: MJIVRKPEXXHNJT-UHFFFAOYSA-N
