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Product Description
4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA inhibits proliferation of SK-BR-3 breast-derived cell lines, HT29 colon-derived cell lines, leukemia-derived U937 tumor cell line, JA16, HL60 and K562 cell lines with EC50 values of 1.1 μM, 0.95 μM, 0.12 μM, 0.24 μM, 0.85 μM and 1.3 μM, respectively. It is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA.
4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA inhibits proliferation of SK-BR-3 breast-derived cell lines, HT29 colon-derived cell lines, leukemia-derived U937 tumor cell line, JA16, HL60 and K562 cell lines with EC50 values of 1.1 μM, 0.95 μM, 0.12 μM, 0.24 μM, 0.85 μM and 1.3 μM, respectively. It is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA.
Biovision | B2800 | 4-Iodo-SAHA DataSheet
Alternate Name/Synonyms: 4-iodo-SAHA, 4-Iodo Suberoylanilide Hydroxamic Acid, N1-hydroxy-N8-(4-iodophenyl)octanediamide, N~1~-Hydroxy-N~8~-(4-iodophenyl)octanediamide
Appearance: Crystalline solid
Formulation:
CAS Number: 1219807-87-0
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₁₄H₁₉IN₂O₃
Molecular Weight: 390.22
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~ 30 mg/ml in DMSO and DMF in 0, ~ 0.2 mg/ml in in Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A hydrophobic derivative of HDAC inhibitor SAHA
MDL Number:
PubChem CID: 46205754
SMILES: C1=CC(=CC=C1NC(=O)CCCCCCC(=O)NO)I
InChi: 1S/C14H19IN2O3/c15-11-7-9-12(10-8-11)16-13(18)5-3-1-2-4-6-14(19)17-20/h7-10,20H,1-6H2,(H,16,18)(H,17,19)
InChi Key: BYVHZKAHBXINPL-UHFFFAOYSA-N
