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Product Description
ACE-2 substrate, Fluorogenic is a useful fluorogenic substrate for angiotensin converting enzyme-2 (ACE-2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike Mca-YVADAPK(Dnp)-OH (Cat. No. B2717), this substrate is not cleaved by caspases. This peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. This substrate is useful for inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm.
ACE-2 substrate, Fluorogenic is a useful fluorogenic substrate for angiotensin converting enzyme-2 (ACE-2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike Mca-YVADAPK(Dnp)-OH (Cat. No. B2717), this substrate is not cleaved by caspases. This peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. This substrate is useful for inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm.
Biovision | B2726 | ACE-2 Substrate, Fluorogenic DataSheet
Alternate Name/Synonyms: Mca-Ala-Pro-Lys(Dnp)-OH [Mca=(7-methoxycoumarin-4-yl)acetyl;Dnp=2,4-dinitrophenyl],Mca-APK(Dnp),ACE2 Substrate
Appearance: Yellow solid
Formulation:
CAS Number: N/A
Structure Available?: No
Peptide sequence: Mca-Ala-Pro-Lys(Dnp)-OH
Salt Form: No
Molecular Formula: C₃₂H₃₇N₆O₁₂
Molecular Weight: 697.7
Cell-Permeable?: TRUE
Purity: ≥95% by HPLC
Solubilities: ~2 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A fluorogenic ACE-2 (Angiotensin I-converting enzyme 2) substrate
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