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Product Description
AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the frequency of volume-induced urinary bladder contractions, without reducing the amplitude of contraction in a rat model. It inhibits the response to noxious bladder stimulation at 10 mg/kg. AMTB also inhibits the sodium channel (Nav) isoforms Nav1.1-1.9 with IC₅₀ values of 2 µM-14.8 µM and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells with IC₅₀ values of ~23.7 µM and 17.3 µM, respectively in a TRPM8-independent manner.
AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the frequency of volume-induced urinary bladder contractions, without reducing the amplitude of contraction in a rat model. It inhibits the response to noxious bladder stimulation at 10 mg/kg. AMTB also inhibits the sodium channel (Nav) isoforms Nav1.1-1.9 with IC₅₀ values of 2 µM-14.8 µM and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells with IC₅₀ values of ~23.7 µM and 17.3 µM, respectively in a TRPM8-independent manner.
Biovision | B2978 | AMTB hydrochloride DataSheet
Alternate Name/Synonyms: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(thiophen-2-ylmethyl)benzamide, hydrochloride; N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide, monohydrochloride; N-(3-aminopropyl)-2-((3-methylbenzyl)oxy)-N-(thiophen-2-ylmethyl)benzamide hydrochloride
Appearance: Solid
Formulation:
CAS Number: 926023-82-7
Structure Available?: True
Peptide sequence:
Salt Form: true
Molecular Formula: C₂₃H₂₇ClN₂O₂S
Molecular Weight: 430.99
Cell-Permeable?: True
Purity: 99%
Solubilities: ~40 mg/ml in water and DMSO in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An antagonist of TRPM8
MDL Number:
PubChem CID: 16095383
SMILES: CC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl
InChi: InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
InChi Key: UDXGBANGPYONOK-UHFFFAOYSA-N
