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Product Description
ASN-002 (Gusacitinib) is a potent dual inhibitor of SYK/JAK kinases. ASN-002 displays strong antitumor activity in both hematological and solid tumor xenograft models. ASN-002 strongly suppresses the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively.
ASN-002 (Gusacitinib) is a potent dual inhibitor of SYK/JAK kinases. ASN-002 displays strong antitumor activity in both hematological and solid tumor xenograft models. ASN-002 strongly suppresses the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively.
Biovision | B3318 | ASN-002 (GUSACITINIB) DataSheet
Alternate Name/Synonyms: ASN002 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile
Appearance: Crystalline solid
Formulation:
CAS Number: 1425381-60-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₈N₈O₂
Molecular Weight: 460.54
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >50 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent dual inhibitor of SYK/JAK kinases
MDL Number:
PubChem CID: 71269142
SMILES: C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
InChi: InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
InChi Key: NLFLXLJXEIUQDL-UHFFFAOYSA-N
