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Product Description
AZD-4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM). It displays rapid induction of apoptosis and subsequent cell death broadly across hematologic cancer models in vitro, and MCL-1 depletion in a dose- and time-dependent manner.
AZD-4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM). It displays rapid induction of apoptosis and subsequent cell death broadly across hematologic cancer models in vitro, and MCL-1 depletion in a dose- and time-dependent manner.
Biovision | B3319 | AZD-4573 DataSheet
Alternate Name/Synonyms: AZD4573 Cyclohexanecarboxamide, 3-(acetylamino)-N-[5-chloro-4-(5,6-dihydro-5,5-dimethyl-4H-pyrrolo[1,2-b]pyrazol-3-yl)-2-pyridinyl]-, (1S,3R)-
Appearance: Crystalline solid
Formulation:
CAS Number: 2057509-72-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₈ClN₅O₂
Molecular Weight: 429.94
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: >40 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent CDK9 inhibitor
MDL Number:
PubChem CID: 124155204
SMILES: CC(=O)NC1CCCC(C1)C(=O)NC2=NC=C(C(=C2)C3=C4CC(CN4N=C3)(C)C)Cl
InChi: InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1
InChi Key: AVIWDYSJSPOOAR-LSDHHAIUSA-N
