Product Description
Orally active PI-3 kinase inhibitor; Dual PI3K/mTOR inhibition; BEZ235 showed high target specificity and demonstrated anti-proliferative activity against tumor cell lines in animal models of cancer.
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.
Biovision | 1626 | BEZ235 (NVP-BEZ235) DataSheet
Alternate Name/Synonyms: NVP-BEZ235
Appearance: Off-white to pale yellow solid
Formulation: N/A
CAS Number: 915019-65-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₀H₂₃N₅O
Molecular Weight: 469.55
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (10 mM)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A PI3 Kinase inhibitor
MDL Number: MFCD10565944
PubChem CID: 11977753
SMILES: CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
InChi: InChI=1S/C30H23N5O/c1-30(2, 18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16- 21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
InChi Key: JOGKUKXHTYWRGZ-UHFFFAOYSA-N