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Product Description
Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It inhibits pre-mRNA splicing with an IC₅₀ of 0.5 mM.
Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It inhibits pre-mRNA splicing with an IC₅₀ of 0.5 mM.
Biovision | B2817 | Butyrolactone 3 DataSheet
Alternate Name/Synonyms: rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid
Appearance: Crystalline solid
Formulation:
CAS Number: 778649-18-6
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₉H₁₂O₄
Molecular Weight: 184.19
Cell-Permeable?: False
Purity: ≥95%
Solubilities: ~2 mg/ml in PBS, pH 7.2 in 0, ~14 mg/ml in ethanol and DMSO in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of histone acetyltransferase Gcn5
MDL Number:
PubChem CID: 10081070
SMILES: CCCC1C(C(=C)C(=O)O1)C(=O)O
InChi: InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
InChi Key: SRQUTZJZABSZRQ-NKWVEPMBSA-N
