Euro
USD
British Pound
NULL
Product Description
CEP-33779 is a potent and orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors, reduces angiogenesis, and reduces proliferation of tumor cells.
CEP-33779 is a potent and orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors, reduces angiogenesis, and reduces proliferation of tumor cells.
Biovision | B2473 | CEP-33779 DataSheet
Alternate Name/Synonyms: N-(3-(4-methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; CEP33779
Appearance: Yellow solid
Formulation:
CAS Number: 1257704-57-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₆N₆O₂S
Molecular Weight: 462.57
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: ~50 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A highly selective JAK2 inhibitor
MDL Number:
PubChem CID: 57336812
SMILES: CN1CCN(CC1)C2=CC(=CC=C2)NC3=NN4C=CC=C(C4=N3)C5=CC=C(C=C5)S(=O)(=O)C
InChi: InChI=1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-6-3-5-19(17-20)25-24-26-23-22(7-4-12-30(23)27-24)18-8-10-21(11-9-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)
InChi Key: RFZKSQIFOZZIAQ-UHFFFAOYSA-N
