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Product Description
Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin.
Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin.
Biovision | B2689 | Cilastatin DataSheet
Alternate Name/Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
Appearance: White to off-white solid
Formulation:
CAS Number: 82009-34-5
Structure Available?: TRUE
Peptide sequence: N/A
Salt Form: FALSE
Molecular Formula: C₁₆H₂₆N₂O₅S
Molecular Weight: 358.5
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~ 10 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A dipeptidase (dehydropeptidase I inhibitor
MDL Number: MFCD00867379
PubChem CID: 6435415
SMILES: OC([C@@H](N)CSCCCC/C=C(C(O)=O)\NC([C@@H]1C(C)(C)C1)=O)=O
InChi: InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
InChi Key: DHSUYTOATWAVLW-WFVMDLQDSA-N
