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Product Description
Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Dabigatran selectively and reversibly inhibits human thrombin (Ki = 4.5 nM) as well as thrombin-induced platelet aggregation (IC50 = 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran displays concentration-dependent anticoagulant effects in various species in vitro.
Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Dabigatran selectively and reversibly inhibits human thrombin (Ki = 4.5 nM) as well as thrombin-induced platelet aggregation (IC50 = 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran displays concentration-dependent anticoagulant effects in various species in vitro.
Biovision | B2552 | Dabigatran Etexilate DataSheet
Alternate Name/Synonyms: BIBR 953, (E)-ethyl 3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate, BIBR953, Pradaxa, BIBR-953
Appearance: Crystalline solid
Formulation:
CAS Number: 211915-06-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form:
Molecular Formula: C₃₄H₄₁N₇O₅
Molecular Weight: 627.73
Cell-Permeable?: True
Purity: ≥98%
Solubilities: 0.5 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A reversible and selective, direct thrombin inhibitor (DTI)
MDL Number:
PubChem CID: 6445226
SMILES: CCCCCCOC(=O)N=C(C1=CC=C(C=C1)NCC2=NC3=C(N2C)C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4)N
InChi: InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)
InChi Key: KSGXQBZTULBEEQ-UHFFFAOYSA-N
