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Product Description
Ditolylguanidine is a sigma receptor (σR) agonist with neuroprotective activity. It shows Kd values of 21.9 nM and 57.4 nM for σ2 and σ1 receptor respectively. Combined treatment with Ditolylguanidine (5 mg/kg) and memantine induces antidepressant-like effect in rats. Sigma receptor modulators are predicted to show activity against SARS-Cov-2, based on viral assay screens and interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.
Ditolylguanidine is a sigma receptor (σR) agonist with neuroprotective activity. It shows Kd values of 21.9 nM and 57.4 nM for σ2 and σ1 receptor respectively. Combined treatment with Ditolylguanidine (5 mg/kg) and memantine induces antidepressant-like effect in rats. Sigma receptor modulators are predicted to show activity against SARS-Cov-2, based on viral assay screens and interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.
Biovision | B3044 | Ditolylguanidine DataSheet
Alternate Name/Synonyms: DTG; DOTG; 1,3-Di-o-tolylguanidine; 1,2-bis(2-methylphenyl)guanidine; {imino[(2-methylphenyl)amino]methyl}(2-methylphenyl)amine; 1,3-di-ortho-tolyl-guanidine
Appearance: White to Off-White powder
Formulation:
CAS Number: 97-39-2
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₁₅H₁₇N₃
Molecular Weight: 239.32
Cell-Permeable?: FALSE
Purity: ≥98%
Solubilities: ~6 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A sigma receptor agonist with neuroprotective activity
MDL Number: MFCD00008513
PubChem CID: 7333
SMILES: CC1=CC=CC=C1NC(=NC2=CC=CC=C2C)N
InChi: InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
InChi Key: OPNUROKCUBTKLF-UHFFFAOYSA-N
