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Product Description
DTP3 is a potent and selective GADD45β/MKK7 inhibitor, that inhibits cancer-selective NF-kB survival pathway. DTP3 specifically kills MM cells, ex vivo and in vivo, ablating MM xenografts in mice, with no apparent adverse effects, nor evident toxicity to healthy cells.
DTP3 is a potent and selective GADD45β/MKK7 inhibitor, that inhibits cancer-selective NF-kB survival pathway. DTP3 specifically kills MM cells, ex vivo and in vivo, ablating MM xenografts in mice, with no apparent adverse effects, nor evident toxicity to healthy cells.
Biovision | B3310 | DTP3 DataSheet
Alternate Name/Synonyms: DTP-3 (R)-2-((R)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-N-((R)-1-amino-1-oxo-3-phenylpropan-2-yl)-5-((diaminomethylene)amino)pentanamide
Appearance: Crystalline solid
Formulation:
CAS Number: 1809784-29-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₃₅N₇O₅
Molecular Weight: 525.61
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective GADD45β/MKK7 inhibitor
MDL Number:
PubChem CID: 86295191
SMILES: O=C(N[C@H](CC1=CC=CC=C1)C(N)=O)[C@H](NC([C@H](NC(C)=O)CC2=CC=C(O)C=C2)=O)CCC/N=C(N)\N
InChi: InChI=1S/C26H35N7O5/c1-16(34)31-22(15-18-9-11-19(35)12-10-18)25(38)32-20(8-5-13-30-26(28)29)24(37)33-21(23(27)36)14-17-6-3-2-4-7-17/h2-4,6-7,9-12,20-22,35H,5,8,13-15H2,1H3,(H2,27,36)(H,31,34)(H,32,38)(H,33,37)(H4,28,29,30)/t20-,21-,22-/m1/s1
InChi Key: AOUZPXZGMZUQQS-YPAWHYETSA-N
