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Product Description
Emricasan (PF-03491390) is an irreversible pan-caspase inhibitor. In a mouse model of α-Fas-induced acute liver injury, the orally-administered caspase inhibitor Emricasan was retained in the liver for prolonged periods with a low systemic exposure.
Emricasan (PF-03491390) is an irreversible pan-caspase inhibitor. In a mouse model of α-Fas-induced acute liver injury, the orally-administered caspase inhibitor Emricasan was retained in the liver for prolonged periods with a low systemic exposure.
Biovision | B2596 | Emricasan DataSheet
Alternate Name/Synonyms: (S)-3-((S)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid, PF-03491390, IDN-6556
Appearance: White to off-white solid
Formulation:
CAS Number: 254750-02-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₇F₄N₃O₇
Molecular Weight: 569.5
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: ~30 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A caspase inhibitor
MDL Number:
PubChem CID: 12000240
SMILES: CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C
InChi: InChI=1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,36)/t12-,17-/m0/s1
InChi Key: SCVHJVCATBPIHN-SJCJKPOMSA-N
