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Product Description
JNJ-17203212 is a reversible and potent antagonist of transient receptor potential vanilloid 1 (TRPV1) with pKi values of 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively. It Inhibits capsaicin- and low pH- induced channel activation with pIC₅₀ values of 6.32 and 7.23 respectively. Intraperitoneal administration of JNJ17203212 (20 mg/kg) attenuates capsaicin evoked coughs. Chronic administration of JNJ-17203212 (30 mg/kg, s.c., twice daily) shows analgesic activity in an in vivo model of bone cancer pain.
JNJ-17203212 is a reversible and potent antagonist of transient receptor potential vanilloid 1 (TRPV1) with pKi values of 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively. It Inhibits capsaicin- and low pH- induced channel activation with pIC₅₀ values of 6.32 and 7.23 respectively. Intraperitoneal administration of JNJ17203212 (20 mg/kg) attenuates capsaicin evoked coughs. Chronic administration of JNJ-17203212 (30 mg/kg, s.c., twice daily) shows analgesic activity in an in vivo model of bone cancer pain.
Biovision | B2974 | JNJ-17203212 DataSheet
Alternate Name/Synonyms: 4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
Appearance: Solid
Formulation:
CAS Number: 821768-06-3
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₇H₁₅F₆N₅O
Molecular Weight: 419.32
Cell-Permeable?: False
Purity: 98%
Solubilities: ~20 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An antagonist of TRPV1
MDL Number: MFCD12828764
PubChem CID: 11339118
SMILES: C1CN(CCN1C2=C(C=CC=N2)C(F)(F)F)C(=O)NC3=NC=C(C=C3)C(F)(F)F
InChi: InChI=1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
InChi Key: JFRYYGVYCWYIDQ-UHFFFAOYSA-N
