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Product Description
L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens.
L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens.
Biovision | B2812 | L-α-Hydroxyglutaric Acid Disodium Salt DataSheet
Alternate Name/Synonyms: disodium;(2S)-2-hydroxypentanedioate, Sodium (S)-2-hydroxypentanedioate, Disodium (S)-2-hydroxyglutarate, (S)-2-Hydroxypentanedioic acid disodium salt
Appearance: Crystalline solid
Formulation:
CAS Number: 63512-50-5
Structure Available?: True
Peptide sequence:
Salt Form: True
Molecular Formula: C₅H₆Na₂O₅
Molecular Weight: 192.08
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~10 mg/ml in PBS in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: L-α-Hydroxyglutaric Acid increases in 2-hydroxyglutaric aciduria.
MDL Number:
PubChem CID: 56845267
SMILES: C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+]
InChi: InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
InChi Key: DZHFTEDSQFPDPP-QTNFYWBSSA-L
