Euro
USD
British Pound
NULL
Product Description
L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is cytotoxic to breast cancer cell lines, especially those derived from triple-negative breast cancer cells. It potently suppresses tumor growth and histone acetylation of MDA-MB-468 xenografts.
L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is cytotoxic to breast cancer cell lines, especially those derived from triple-negative breast cancer cells. It potently suppresses tumor growth and histone acetylation of MDA-MB-468 xenografts.
Biovision | B2859 | L002 DataSheet
Alternate Name/Synonyms: [(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 4-methoxybenzenesulfonate; 4-(4-methoxyphenylsulfonyloxyimino)-2,6-dimethylcyclohexa-2,5-dienone; (3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino 4-methoxybenzene-1-sulfonate; (3,5-dimethyl-4-oxocyclohexa-2,5-dienylidene)azamethyl 4-methoxybenzenesulfonate; 2,6-dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; NSC764414; p300/CBP Inhibitor VI
Appearance: A crystalline solid
Formulation:
CAS Number: 321695-57-2
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₅H₁₅NO₅S
Molecular Weight: 321.35
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~1 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of p300 histone acetyltransferase
MDL Number:
PubChem CID: 2221149
SMILES: CC1=CC(=NOS(=O)(=O)C2=CC=C(C=C2)OC)C=C(C1=O)C
InChi: InChI=1S/C15H15NO5S/c1-10-8-12(9-11(2)15(10)17)16-21-22(18,19)14-6-4-13(20-3)5-7-14/h4-9H,1-3H3
InChi Key: VEWFTYOFWIXCIO-UHFFFAOYSA-N
