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Product Description
LDN-212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Displays selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC₅₀ values < 100 nM).
LDN-212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Displays selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC₅₀ values < 100 nM).
Biovision | B2641 | LDN-212854 DataSheet
Alternate Name/Synonyms: LDN212854; 5-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Appearance: Yellow solid
Formulation:
CAS Number: 1432597-26-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₂N₆
Molecular Weight: 406.48
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >20 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent bone morphogenetic protein type I (ALK) inhibitor
MDL Number:
PubChem CID: 60182388
SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=C6C=CC=NC6=CC=C5)N=C3
InChi: InChI=1S/C25H22N6/c1-3-21(22-4-2-10-27-24(22)5-1)23-16-29-31-17-19(15-28-25(23)31)18-6-8-20(9-7-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
InChi Key: BBDGBGOVJPEFBT-UHFFFAOYSA-N
