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Product Description
LIN28 is an RNA-binding protein that regulates the maturation of the let-7 microRNAs through its two distinct cold shock and zinc-knuckle domains. LIN28 inhibitor LI71 binds the cold shock domain of LIN28 and suppresses the activity of LIN28 against let-7 in leukemia cells and embryonic stem cells. LI71 shows an IC₅₀ of ~7 μM in the fluorescence polarization assay using LIN28 and pre-elements of members of the let-7 family.
LIN28 is an RNA-binding protein that regulates the maturation of the let-7 microRNAs through its two distinct cold shock and zinc-knuckle domains. LIN28 inhibitor LI71 binds the cold shock domain of LIN28 and suppresses the activity of LIN28 against let-7 in leukemia cells and embryonic stem cells. LI71 shows an IC₅₀ of ~7 μM in the fluorescence polarization assay using LIN28 and pre-elements of members of the let-7 family.
Biovision | B3073 | LIN28 inhibitor LI71 DataSheet
Alternate Name/Synonyms: 4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid
Appearance: White powder
Formulation:
CAS Number: 1357248-83-9
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₂₁H₂₁NO₃
Molecular Weight: 335.4
Cell-Permeable?: TRUE
Purity: ≥97%
Solubilities: Soluble in methanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of LIN28
MDL Number: MFCD07363437
PubChem CID: 6541811
SMILES: CCOC1=CC=CC2=C1NC(C3C2C=CC3)C4=CC=C(C=C4)C(=O)O
InChi: InChI=1S/C21H21NO3/c1-2-25-18-8-4-7-17-15-5-3-6-16(15)19(22-20(17)18)13-9-11-14(12-10-13)21(23)24/h3-5,7-12,15-16,19,22H,2,6H2,1H3,(H,23,24)/t15-,16+,19+/m1/s1
InChi Key: QWJMABCFVYELBB-GJYPPUQNSA-N
