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Product Description
LY-2409881 is a potent and selective inhibitor of IκB kinase β (IKK2; IC50 = 30 nM). It inhibits IKK1 and other common kinases only at ≥10-fold higher concentrations. LY2-409881 inhibits constitutively activated NF-κB, and causes concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells.
LY-2409881 is a potent and selective inhibitor of IκB kinase β (IKK2; IC50 = 30 nM). It inhibits IKK1 and other common kinases only at ≥10-fold higher concentrations. LY2-409881 inhibits constitutively activated NF-κB, and causes concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells.
Biovision | B3213 | LY-2409881 DataSheet
Alternate Name/Synonyms: 2-[5-chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropyl-benzo[b]thiophene-4-carboxamide, trihydrochloride
Appearance: Crystalline solid
Formulation:
CAS Number: 946518-60-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₉ClN₆OS • 3HCl
Molecular Weight: 594.4
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >10 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective IκB kinase inhibitor
MDL Number:
PubChem CID: 68856073
SMILES: O=C(NC1CC1)C2=C(C=C(C3=C(Cl)C=NC(NCCCN4CCN(C)CC4)=N3)S5)C5=CC=C2.Cl.Cl.Cl
InChi: InChI=1S/C24H29ClN6OS.3ClH/c1-30-10-12-31(13-11-30)9-3-8-26-24-27-15-19(25)22(29-24)21-14-18-17(4-2-5-20(18)33-21)23(32)28-16-6-7-16;;;/h2,4-5,14-16H,3,6-13H2,1H3,(H,28,32)(H,26,27,29);3*1H
InChi Key: IEXCRLAGBWKVPW-UHFFFAOYSA-N
