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Product Description
Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis and Eczema. It inhibits TNFα secretion from activated canine peripheral blood derived mononuclear cells with an IC₅₀ value of approximately 0.2 nM. It shows beneficial effects in inflammatory and pruritic skin diseases in dogs.
Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis and Eczema. It inhibits TNFα secretion from activated canine peripheral blood derived mononuclear cells with an IC₅₀ value of approximately 0.2 nM. It shows beneficial effects in inflammatory and pruritic skin diseases in dogs.
Biovision | B3078 | Mapracorat DataSheet
Alternate Name/Synonyms: BOL-303242X; ZK-245186; (2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol; 7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-gamma,gamma-dimethyl-alpha-(((2-methyl-5-quinolinyl)amino)methyl)-alpha-(trifluoromethyl)-, (alphaR)-
Appearance: Yellow crystals
Formulation:
CAS Number: 887375-26-0
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₂₅H₂₆F₄N₂O₂
Molecular Weight: 462.49
Cell-Permeable?: TRUE
Purity: >98%
Solubilities: ~33 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: a selective glucocorticoid receptor agonist
MDL Number: MFCD19443722
PubChem CID: 24795088
SMILES: CC1=NC2=C(C=C1)C(=CC=C2)NCC(CC(C)(C)C3=CC(=CC4=C3OCC4)F)(C(F)(F)F)O
InChi: InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1
InChi Key: VJGFOYBQOIPQFY-XMMPIXPASA-N
