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Product Description
N4-Hydroxycytidine is a ribonucleoside analog with broad-spectrum antiviral activity. The prodrug of N4-hydroxycytidine is EIDD-2801. N4-Hydroxycytidine is active against influenza, Ebola, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)and Venezuelan equine encephalitis virus (VEEV). It inhibits replication of SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells with IC₅₀ values of 0.08 μM and 0.15 μM respectively. N4-Hydroxycytidine (100 and 400 mg/kg twice per day) reduces lung viral titers in a mouse model of Respiratory Syncytial Virus (RSV) infection.
N4-Hydroxycytidine is a ribonucleoside analog with broad-spectrum antiviral activity. The prodrug of N4-hydroxycytidine is EIDD-2801. N4-Hydroxycytidine is active against influenza, Ebola, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)and Venezuelan equine encephalitis virus (VEEV). It inhibits replication of SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells with IC₅₀ values of 0.08 μM and 0.15 μM respectively. N4-Hydroxycytidine (100 and 400 mg/kg twice per day) reduces lung viral titers in a mouse model of Respiratory Syncytial Virus (RSV) infection.
Biovision | B3039 | N4-Hydroxycytidine DataSheet
Alternate Name/Synonyms: EIDD-1931; NHC; Uridine, 4-oxime; Beta-D-N4-hydroxycytidine; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-hydroxyamino-1H-pyrimidin-2-one
Appearance: White solid
Formulation:
CAS Number: 496036
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₉H₁₃N₃O₆
Molecular Weight: 259.22
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~20 mg/ml in DMSO; ~10 mg/ml in PBS, pH7.2; ~10 mg/ml in DMF
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A ribonucleoside analog with broad-spectrum antiviral activity
MDL Number: MFCD01675695
PubChem CID: 197020
SMILES: C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O
InChi: InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1
InChi Key: XCUAIINAJCDIPM-XVFCMESISA-N
