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Product Description
Orelabrutinib is a potent and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.
Orelabrutinib is a potent and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.
Biovision | B2789 | Orelabrutinib (ICP-022) DataSheet
Alternate Name/Synonyms: ICP022,2-(4-phenoxyphenyl)-6-[1-(prop-2-enoyl)piperidin- 4-yl]pyridine-3-carboxamide
Appearance: Crystalline solid
Formulation:
CAS Number: 1655504-04-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₅N₃O₃
Molecular Weight: 427.49
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >50 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A Bruton's tyrosine kinase (BTK) inhibitor
MDL Number:
PubChem CID: 91667513
SMILES: C=CC(=O)N1CCC(CC1)C2=NC(=C(C=C2)C(=O)N)C3=CC=C(C=C3)OC4=CC=CC=C4
InChi: InChI=1S/C26H25N3O3/c1-2-24(30)29-16-14-18(15-17-29)23-13-12-22(26(27)31)25(28-23)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-13,18H,1,14-17H2,(H2,27,31)
InChi Key: MZPVEMOYADUARK-UHFFFAOYSA-N
