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Product Description
Quisinostat is an inhibitor of histone deacetylase (HDAC). It shows activity toward HDAC enzymes with highest potency for recombinant HDAC1 (IC₅₀ = 0.11 nM) in vitro. The IC₅₀ values for HDAC 2 and 3 are 0.33 nM and 4.8 nM respectively. It shows broad spectrum antiproliferative activity (IC₅₀ values of 3.1-246 nM) in lung, breast, colon, prostate, brain and ovarian cancer cell lines.
Quisinostat is an inhibitor of histone deacetylase (HDAC). It shows activity toward HDAC enzymes with highest potency for recombinant HDAC1 (IC₅₀ = 0.11 nM) in vitro. The IC₅₀ values for HDAC 2 and 3 are 0.33 nM and 4.8 nM respectively. It shows broad spectrum antiproliferative activity (IC₅₀ values of 3.1-246 nM) in lung, breast, colon, prostate, brain and ovarian cancer cell lines.
Biovision | B3066 | Quisinostat hydrochloride DataSheet
Alternate Name/Synonyms: N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide hydrochloride; JNJ-26481585
Appearance: Solid
Formulation:
CAS Number: 1083078-98-1
Structure Available?: TRUE
Peptide sequence:
Salt Form: TRUE
Molecular Formula: C₂₁H₂₇ClN₆O₂
Molecular Weight: 430.93
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~20 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of histone deacetylase
MDL Number:
PubChem CID: 25067557
SMILES: CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl
InChi: InChI=1S/C21H26N6O2.ClH/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29;/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28);1H
InChi Key: TWNOICNTTFKOHQ-UHFFFAOYSA-N
