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Product Description
R-59-022 is an inhibitor of Diacylglycerol (DAG) kinase with an IC₅₀ of 2.8 µM. The inhibition of Diacylglycerol kinase results in increased DAG-dependent protein kinase C (PKC) activity and potentiates aggregation of thrombin-stimulated platelets. R59022 inhibits thromboxane A(2) analogue U46619-induced contractions in mouse aorta and porcine coronary artery at concentrations of 0.1 μM to 30 μM. R-59-022 (10 µM) induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells.
R-59-022 is an inhibitor of Diacylglycerol (DAG) kinase with an IC₅₀ of 2.8 µM. The inhibition of Diacylglycerol kinase results in increased DAG-dependent protein kinase C (PKC) activity and potentiates aggregation of thrombin-stimulated platelets. R59022 inhibits thromboxane A(2) analogue U46619-induced contractions in mouse aorta and porcine coronary artery at concentrations of 0.1 μM to 30 μM. R-59-022 (10 µM) induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells.
Biovision | B2975 | R-59-022 DataSheet
Alternate Name/Synonyms: 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one; Diacylglycerol Kinase Inhibitor I
Appearance: A crystalline solid
Formulation:
CAS Number: 93076-89-2
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₇H₂₆FN₃OS
Molecular Weight: 459.58
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~5 mg/ml in ethanol and DMSO in 0, ~20 mg/ml in DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of Diacylglycerol kinase
MDL Number:
PubChem CID: 3012
SMILES: CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=CC=C4)C5=CC=C(C=C5)F)CC3
InChi: InChI=1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChi Key: MFVJXLPANKSLLD-UHFFFAOYSA-N
