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Product Description
SA4503 is a potent sigma-1 (σ1 receptor) agonist. It shows 100 fold higher affinity for σ1 than σ2 receptor with IC₅₀ values of 17.4 nM and 1784 nM against 200 nM (+)-pentazocine for binding σ receptor in guinea pig brain membranes. It shows Ki values of 4.6 nM and 63.1 nM for σ1 and σ2 sites respectively in guinea pig brain homogenates. It enhances recovery of lost sensorimotor function in a rat model of stroke. Based on viral screens, modulators of sigma receptor are predicted to show activity against SARS-CoV-2.
SA4503 is a potent sigma-1 (σ1 receptor) agonist. It shows 100 fold higher affinity for σ1 than σ2 receptor with IC₅₀ values of 17.4 nM and 1784 nM against 200 nM (+)-pentazocine for binding σ receptor in guinea pig brain membranes. It shows Ki values of 4.6 nM and 63.1 nM for σ1 and σ2 sites respectively in guinea pig brain homogenates. It enhances recovery of lost sensorimotor function in a rat model of stroke. Based on viral screens, modulators of sigma receptor are predicted to show activity against SARS-CoV-2.
Biovision | B3046 | SA4503 dihydrochloride DataSheet
Alternate Name/Synonyms: Cutamesine dihydrochloride; 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride; 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine 2HCl; AGY94806 dihydrochloride
Appearance: White to Off-White Solid
Formulation:
CAS Number: 165377-44-6
Structure Available?: TRUE
Peptide sequence:
Salt Form: TRUE
Molecular Formula: C₂₃H₃₄Cl₂N₂O₂
Molecular Weight: 441.43
Cell-Permeable?: FALSE
Purity: ≥98%
Solubilities: ~5 mg/ml in PBS, pH 7.2; ~2 mg/ml in water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: a potent sigma-1 (σ1 receptor) agonist
MDL Number: MFCD00939308
PubChem CID: 9954941
SMILES: COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl
InChi: InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H
InChi Key: XWOXAKBQEMQMFH-UHFFFAOYSA-N
