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Product Description
SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a concentration of 1 µM.
SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a concentration of 1 µM.
Biovision | B2846 | SGC707 DataSheet
Alternate Name/Synonyms: 1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea; N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea; N-{2-[(2-Oxo-3-azepanyl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide
Appearance: A crystalline solid
Formulation:
CAS Number: 1687736-54-4
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₁₆H₁₈N₄O₂
Molecular Weight: 298.34
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~2 mg/ml in DMSO and DMF in 0, ~5 mg/ml in in Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of PRMT3
MDL Number:
PubChem CID: 90642938
SMILES: C1CCN(C1)C(=O)CNC(=O)NC2=CC3=C(C=C2)C=NC=C3
InChi: InChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
InChi Key: DMIDPTCQPIJYFE-UHFFFAOYSA-N
