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Product Description
STF-083010 is a potent Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. It blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro.
STF-083010 is a potent Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. It blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro.
Biovision | B2528 | STF-083010 DataSheet
Alternate Name/Synonyms: STF083010; N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Appearance: Crystalline solid
Formulation:
CAS Number: 307543-71-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₁₁NO₃S₂
Molecular Weight: 317.38
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >30 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An Ire1 inhibitor
MDL Number:
PubChem CID: 135398515
SMILES: C1=CC=C2C(=C1)C=CC(=C2C=NS(=O)(=O)C3=CC=CS3)O
InChi: InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChi Key: TVIVJHZHPKNDAQ-MHWRWJLKSA-N
