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Product Description
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239 nM. It inhibits TNF-α stimulated phosphorylation of c-Jun in cells with an EC₅₀ of 6.23 μM. It restores insulin sensitivity in a mouse model of type-2 diabetes.
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239 nM. It inhibits TNF-α stimulated phosphorylation of c-Jun in cells with an EC₅₀ of 6.23 μM. It restores insulin sensitivity in a mouse model of type-2 diabetes.
Biovision | B2923 | SU 3327 DataSheet
Alternate Name/Synonyms: 5-((5-nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-amine; 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine; JNK Inhibitor XIII; BDBM29315
Appearance: Solid
Formulation:
CAS Number: 40045-50-9
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₅H₃N₅O₂S₃
Molecular Weight: 261.3
Cell-Permeable?: True
Purity: 95%
Solubilities: 4 mg/ml in in Ethanol, 50 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of JNK
MDL Number:
PubChem CID: 11837140
SMILES: C1=C(SC(=N1)SC2=NN=C(S2)N)[N+](=O)[O-]
InChi: InChI=1S/C5H3N5O2S3/c6-3-8-9-5(14-3)15-4-7-1-2(13-4)10(11)12/h1H,(H2,6,8)
InChi Key: NQQBNZBOOHHVQP-UHFFFAOYSA-N
