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Product Description
SZL P1-41 is a specific Skp2 inhibitor that binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Displays antitumor effects in multiple animal models and cancer cell lines.
SZL P1-41 is a specific Skp2 inhibitor that binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Displays antitumor effects in multiple animal models and cancer cell lines.
Biovision | B3325 | SZL-P1-41 DataSheet
Alternate Name/Synonyms: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Appearance: Off-white solid
Formulation:
CAS Number: 222716-34-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₄N₂O₃S
Molecular Weight: 420.52
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: ~2 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective Skp2 inhibitor
MDL Number:
PubChem CID: 1286902
SMILES: OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O
InChi: InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
InChi Key: JKIXLEKBXHMXTN-UHFFFAOYSA-N
