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Product Description
TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values of 14.3 and 18.7 μM, respectively. Chronic administration of TCS 5861528 (30 mg/kg twice daily) in diabetic rats attenuates pain-related behavior and development of mechanical hypersensitivity.
TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values of 14.3 and 18.7 μM, respectively. Chronic administration of TCS 5861528 (30 mg/kg twice daily) in diabetic rats attenuates pain-related behavior and development of mechanical hypersensitivity.
Biovision | B2977 | TCS 5861528 DataSheet
Alternate Name/Synonyms: N-(4-butan-2-ylphenyl)-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide; Chembridge-5861528; 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide; 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
Appearance: Solid
Formulation:
CAS Number: 332117-28-9
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₉H₂₃N₅O₃
Molecular Weight: 369.42
Cell-Permeable?: True
Purity: 97%
Solubilities: ~15 mg/ml in in DMSO, May need ultrasonication or warming in 0, ~30 mg/ml in DMF in 0, ~0.1 mg/ml in in Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective TRPA1 blocker
MDL Number:
PubChem CID: 2873523
SMILES: CCC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C
InChi: InChI=1S/C19H23N5O3/c1-5-12(2)13-6-8-14(9-7-13)21-15(25)10-24-11-20-17-16(24)18(26)23(4)19(27)22(17)3/h6-9,11-12H,5,10H2,1-4H3,(H,21,25)
InChi Key: ZUTUWJYMCADJHD-UHFFFAOYSA-N
