Euro
USD
British Pound
NULL
Product Description
Tiagabine is a selective inhibitor of GABA transporter 1 (GAT-1) and a GABA uptake inhibitor. It shows an IC₅₀ of 49 nM for GAT-1 expressed in CHO cells. It reduces allodynia in a rodent model of neuropathic pain at a dose of 72.8 µmol/kg, ip. It shows anticonvulsant effects and is used in the treatment of epilepsy.
Tiagabine is a selective inhibitor of GABA transporter 1 (GAT-1) and a GABA uptake inhibitor. It shows an IC₅₀ of 49 nM for GAT-1 expressed in CHO cells. It reduces allodynia in a rodent model of neuropathic pain at a dose of 72.8 µmol/kg, ip. It shows anticonvulsant effects and is used in the treatment of epilepsy.
Biovision | B3114 | Tiagabine hydrochloride DataSheet
Alternate Name/Synonyms: Gabitril; (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride; (r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride; (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride
Appearance: White to Beige Powder
Formulation:
CAS Number: 145821-59-6
Structure Available?: TRUE
Peptide sequence:
Salt Form: TRUE
Molecular Formula: C₂₀H₂₆ClNO₂S₂
Molecular Weight: 412.01
Cell-Permeable?: True
Purity: ≥ 98%
Solubilities:
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective inhibitor of GAT-1
MDL Number: MFCD07369025
PubChem CID: 91274
SMILES: CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl
InChi: InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
InChi Key: YUKARLAABCGMCN-PKLMIRHRSA-N
