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Product Description
Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton’s Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton’s Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
Biovision | B2556 | Tirabrutinib hydrochloride DataSheet
Alternate Name/Synonyms: GS4059, ONO-WG-307, GS 4059, GS-4059, ONO-4059, ONO4059 HCl, (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride
Appearance: Crystalline solid
Formulation:
CAS Number: 1439901-97-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₃ClN₆O₃
Molecular Weight: 490.95
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent Bruton's Tyrosine Kinase (BTK) inhibitor
MDL Number:
PubChem CID: 71571562
SMILES: CC#CC(=O)N1CCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl
InChi: InChI=1S/C25H22N6O3.ClH/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19;/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28);1H/t18-;/m1./s1
InChi Key: UQYDCIJFACDXSG-GMUIIQOCSA-N
