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Product Description
Triclabendazole is a benzimidazole anthelminthic drug that binds to tubulin. TCBZ is used to treat liver fluke (Fasciola hepatica) infections in cattle and humans. It is effective against fascioliasis in sheep at a dose of 10 mg/body weight. Triclabendazole (5 μM) protects yeast cells from death induced by α-synuclein, oxidants and heat stress. It decreases the intracellular level of cyclic AMP and triggers the translocation of the stress-resistance transcription factor Msn2 from the cytosol into the nucleus in yeast cells.
Triclabendazole is a benzimidazole anthelminthic drug that binds to tubulin. TCBZ is used to treat liver fluke (Fasciola hepatica) infections in cattle and humans. It is effective against fascioliasis in sheep at a dose of 10 mg/body weight. Triclabendazole (5 μM) protects yeast cells from death induced by α-synuclein, oxidants and heat stress. It decreases the intracellular level of cyclic AMP and triggers the translocation of the stress-resistance transcription factor Msn2 from the cytosol into the nucleus in yeast cells.
Biovision | B3038 | Triclabendazole DataSheet
Alternate Name/Synonyms: Fasinex; 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzimidazole; 5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole
Appearance: White to Off-White Powder
Formulation:
CAS Number: 68786-66-3
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₁₄H₉Cl₃N₂OS
Molecular Weight: 359.66
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~3.6 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A benzimidazole anthelminthic drug that binds to tubulin
MDL Number: MFCD00864519
PubChem CID: 50248
SMILES: CSC1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl
InChi: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
InChi Key: NQPDXQQQCQDHHW-UHFFFAOYSA-N
![Synthetic Triclabendazole [HRP]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/452399/655532/images__81618.1648113406__09603.1648114891.png?c=2 "Synthetic Triclabendazole [HRP]")
