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Product Description
Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).
Vatalanib, Free Base is an inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).
Biovision | 2026 | Vatalanib, Free Base DataSheet
Alternate Name/Synonyms: CGP-79787; PTK 787; ZK222584
Appearance: Off-white solid
Formulation: N/A
CAS Number: 212141-54-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₁₅ClN₄
Molecular Weight: 346.81
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (25 mg/ml) or EtOH (~ 6 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent inhibitor of the VEGFR tyrosine kinases
MDL Number: MFCD08458963
PubChem CID: 151194
SMILES: C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4
InChi: InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24- 25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
InChi Key: YCOYDOIWSSHVCK-UHFFFAOYSA-N
