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Product Description
VEGFR-2 and tubulin inhibitor inhibits polymerization of tubulin with an IC₅₀ of 1.1 μM. It inhibits the receptor tyrosine kinase VEGFR-2 in vitro and VEGFR-2 in cells with an IC₅₀ of 0.21 μM and 0.11 μM respectively. It shows an EC₅₀ of 9 nM for causing G2/M arrest in A431 cells. Mice treated with this inhibitor show less toxicity and normal pathology.
VEGFR-2 and tubulin inhibitor inhibits polymerization of tubulin with an IC₅₀ of 1.1 μM. It inhibits the receptor tyrosine kinase VEGFR-2 in vitro and VEGFR-2 in cells with an IC₅₀ of 0.21 μM and 0.11 μM respectively. It shows an EC₅₀ of 9 nM for causing G2/M arrest in A431 cells. Mice treated with this inhibitor show less toxicity and normal pathology.
Biovision | B2932 | VEGFR-2 & tubulin inhibitor DataSheet
Alternate Name/Synonyms: (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(5-{2-[(pyridin-4-ylmethyl)-amino]-phenyl}-[1,3,4]oxadiazol-2-yl)-amine; Dual VEGFR-2 and tubulin inhibitor
Appearance: Solid
Formulation:
CAS Number: 830333-53-4
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₂H₁₉N₅O₃
Molecular Weight: 401.42
Cell-Permeable?: True
Purity: 95%
Solubilities: Soluble in DMSO in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A dual VEGFR-2 and tubulin inhibitor
MDL Number:
PubChem CID:
SMILES: C1(NC2=CC=C(OCCO3)C3=C2)=NN=C(C4=CC=CC=C4NCC5=CC=NC=C5)O1
InChi: InChI=1S/C22H19N5O3/c1-2-4-18(24-14-15-7-9-23-10-8-15)17(3-1)21-26-27-22(30-21)25-16-5-6-19-20(13-16)29-12-11-28-19/h1-10,13,24H,11-12,14H2,(H,25,27)
InChi Key: IQVQCEHRAJVTIU-UHFFFAOYSA-N
